A novel zinc finger gene is fused to EWS in small round cell tumor
نویسندگان
چکیده
منابع مشابه
EWS-WT1 Chimeric Protein in Desmoplastic Small Round Cell Tumor is a Potent Transactivator of FGFR4
Desmoplastic small round cell tumor (DSRCT) is a rare but highly aggressive malignant tumor that typically involves the abdominal or pelvic peritoneum in children and young adults [1]. This tumor is characterized histologically by solid nests of small round-cell tumor cells expressing epithelial, muscular, and neural markers, surrounded by a dense reactive stroma. This tumor is also characteriz...
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SUMMARY Askin tumor is a peripheral neuroepithelioma originating in chest wall. It is a very aggressive tumor and with Ewing's sarcoma are the most frequent tumors of chest wall. The tumor is composed of small round or ovoid cells arranged in sheets with pseudorossette formation. Some times around vessels, glycogen staining is some times positive in H & E but always positive in E.M. In E.M be...
متن کاملVariant EWS-WT1 chimeric product in the desmoplastic small round cell tumor.
Chromosome translocations found in neoplasms often result in the creation of hybrid genes encoding chimeric proteins. Desmoplastic small round cell tumor (DSRCT) is a recently described aggressive malignancy associated with a unique chromosomal translocation t(11;22)(p13;q12). This translocation has recently been characterized, revealing the rearrangement and fusion of the WT1 gene on chromosom...
متن کاملFusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.
The desmoplastic small round cell tumor (DSRCT) is a recently recognized type of primitive sarcoma defined by a predilection for young males, aggressive clinical behavior, widespread abdominal serosal involvement, and a primitive histological appearance with prominent desmoplasia and striking divergent, multilineage differentiation. Previous cytogenetic case reports have identified a recurrent ...
متن کاملA 8-year survivor of unresectable intrapelvic desmoplastic small round cell tumor treated with concurrent chemoradiotherapy
Desmoplastic small round cell tumor is a rare malignant tumor that occurs primarily in young males. Here, a case of small round cell tumor in an adult male successfully treated with a curative concurrent chemoradiotherapy is presented. A 58-year-old man had an intrapelvic tumor. Surgical resection was attempted, but the tumor was unresectable. Needle biopsy was performed and the diagno...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2000
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1203762